After months of isolation, Isherwood "Ish" Williams, learns that most of the world has fallen to a mysterious illness. Yet despite his instincts to further isolate, Ish leads the charge to develop a new civilization.

Based on Steven Soderbergh's 2009 film of the same title, this anthology series is set in Washington, D.C. in the days leading up to the presidential election and centers on high-end NYC escort Christine (Riley Keough), who offers clients "the girlfriend experience" while leading a double life as a young attorney in training.